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qy8com千赢手机版:教师简介

郭明雄
时间:2016-12-26 13:25:39 阅读量:
职称职务:副教授
学科专业:细胞生物学
研究方向:发育与疾病的关系
实验室位置:qy8com千赢手机版大楼5108室
联系电话:027-68752472,13343469985

E-mail: guomx@whu.edu.cn

 

学习经历:
2003.09 – 2006.12  qy8com千赢手机版 博士
2000.09 – 2003.06  qy8com千赢手机版 硕士
1990.09 – 1994.06  qy8com千赢手机版 学士


主要工作经历与任职情况:
2009.11 – 至今    qy8com千赢手机版 副教授,硕士研究生导师
2012.01 – 2012.12  美国纽约州奥尔巴尼医学院 访问学者
2007.02 – 2009.11  qy8com千赢手机版 讲师
1994.07 – 2000.08  湖北中医药大学基础部 教师


主要社会兼职:
中国细胞生物学学会会员

主要研究领域及兴趣:
1、利用cDNA文库构建、mRNAs和microRNAs表达谱芯片、组织芯片等现代实验技术,结合生物信息学、分子生物学、细胞生物学等研究方法和技术手段,筛选与人类早期胚胎发育相关的新基因(包括蛋白编码基因和microRNAs基因);
2、与人类早期胚胎发育相关新基因的转录调控研究及其在人胚分子发育和恶性肿瘤发生发展过程中的生物学功能探索。


承担课程:
1、生物检测技术(本科生)
2、免疫学实验(本科生)
3、病毒与细胞的关系(研究生)


主持和参与课题项目:
1. 主持:中央高校基本科研业务费专项资金(学科交叉类资助项目)(2042014kf0243),2014-2015;
2. 主持:国家自然科学基金面上项目(31271511),2013-2016;
3. 主持:国家自然科学基金面上项目(30871245),2009-2011;
4. 主持:教育部高校博士点基金新教师项目(200804861004),2009-2011;
5. 参与:国家高技术研究发展计划(863计划)(2006AA02A306),2006-2010


代表性论文(* Co-first author, # Corresponding author
1) Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo #, and Wenxin Li #. Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-containing Zinc Finger Proteins. PLoS One, 2014, Mar 19; 9(3):e92155

2) Yi Lin, Yan Zeng, Fan Zhang, Lu Xue, Zan Huang, Wenxin Li   #,   Mingxiong Guo #.       Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development.   PLoS ONE 2013, 8(8): e69230.

3) Wei Wang *,       Jinyang Cai *, Yingliang Wu, Jun Hu, Zongyun Chen, Wenxin Li,   Mingxiong Guo #, Zan Huang       #. KRAB domain functions as a novel nuclear localization signal by interacting with KAP1.   Cell Mol Life Sci., 2013, 70(20): 3947-3958.
 
  4) Li Hu *, Wei Wang *, Jinyang Cai, Jun Luo, Yi Huang, Shilu Xiong, Wenxin Li,   Mingxiong Guo #. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells.   Oncol Lett., 2013, 6: 49-54.
     
  5) Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang,   Ming-Xiong Guo, Wen-Xin Li   # and Wenhua Li   #. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.   FASEB J., 2013, 27(1): 163-73
       
  6) Wei Wang     *,   Mingxiong Guo *, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li   #, Zan Huang   #.     The Zinc Finger Protein ZNF268 is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling.   J. Biol. Chem., 2012, 287(51): 42856-66.
 
  7) Yan Zeng, Wei Wang, Jian Ma, Xianguo Wang,   Mingxiong Guo   #, Wenxin Li   #.       Knockdown of ZNF268, Which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells.   PLoS ONE   ., 2012, 7(1): e29518.

8) Lu Xue *, Hong-Ling Qiu *, Jian Ma,   Ming-Xiong Guo, Wen-Xin Li   #.     ZNF300, A Recently Identified Human Transcription Factor, Activates the Human IL-2R Beta Promoter through the Overlapping ZNF300/Egr1 Binding Site.       Cell. Mol. Biol. Lett. 2010, 15(4): 530-40.
 
  9) Hong Yi *, Lu Xue *,   Ming-Xiong Guo *, Jian Ma, Yan Zeng, Wei Wang, Jin-Yang Cai, Hai-Ming Hu, Hong-Bing Shu, Yun-Bo Shi   #, Wen-Xin Li   #.         Gene Expression Atlas for Human Embryogenesis.     FASEB J   . 2010, 24(9): 3341-50.

10) Jun-Hua Xu, Tao Wang, Xian-Guo Wang, Xiang-Peng Wu, Zhou-Zhou Zhao, Chen-Gang Zhu, Hong-Ling Qiu, Lu Xue, Huan-Jie Shao,   Ming-Xiong Guo, Wen-Xin Li   #.   PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.   Leukemia Research, 2010, 34(12): 1636-46.

11) Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu,   Mingxiong Guo*, Wenxin Li*.       Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.       Oncol. Rep.   , 2008, 20(5): 1243-8.

12) Di Wang *,   Ming-Xiong Guo *, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li.       Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway.       J. Biol. Chem.,     2008, 283(24): 16299-308.

13)   Mingxiong Guo, Tao Huang, Yejian Cui, Baiqun Pan, Ao Shen, Yuting Sun, Yourong Yi, Yan Wang, Gengfu Xiao, Guihong Sun.         PrP   C interacts with tetraspanin-7 through bovine PrP   154-182 containing alpha-helix 1.       Biochem. Bioph. Res. Co., 2008, 365(1): 154-7.

14) Chengang Zhu, Zhouzhou Zhao,   Mingxiong Guo, Huanjie Shao, Hongling Qiu, Di Wang, Junhua Xu, Lu Xue, Wenxin Li.     The mammalian gene ZNF268 is regulated by hUpf1.   Biochemistry-Moscow, 2008, 73(8): 881-5.

15) Li Xu, Zhouzhou Zhao, Jiqun Sheng, Chenggang Zhu, Hui Liu, Dahe Jiang, Xin Mao,   Mingxiong Guo, and Wenxin Li.     Co-expression of complement regulatory proteins human DAF and MCP with an IRES-mediated dicistronic mammalian vector enhances their cell protective effects.   Biochemistry-Moscow. 2008, 73(9): 1025-30.

16) Hongling Qiu, Lu Xue, Li Gao, Huanjie Shao, Di Wang,   Mingxiong Guo and Wenxin Li.     Identification of the DNA binding element of the human ZNF300 protein.   Cell. Mol. Biol. Lett., 2008, 13(3): 391-403.

17)   Ming-Xiong Guo *, Di Wang *, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li.       Transcription of Human Zinc Finger   ZNF268 Gene Requires an Intragenic Promoter Element.   J. Biol. Chem., 2006, 281(34): 24623-36.

18) Shao H, Zhu C, Zhao Z,   Guo M, Qiu H, Liu H, Wang D, Xue L, Gao L, Sun C, Li W.     KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains.   Int. J. Mol. Med., 2006, 18(3): 457-63.

19) Guihong Sun,   Mingxiong Guo, Ao Shen, Fanghua Mei, Xiaoxue Peng, Rui Gong, Deyin Guo, Jianguo Wu, Po Tien, Gengfu Xiao.     Bovine PrP   Cdirectly interacts with alpha B-crystalline.   FEBS Lett., 2005, 579: 5419-24.  
 
  已申请或授权专利:  
  1. 李文鑫;郭明雄;黄赞;林义. miR-638在抗急性髓系白血病中的应用. 专利申请号:201410466367.2  
2. 李文鑫;   郭明雄; 汪维; 吴淼. 一种突变型载体pEGFP-N1m的构建方法及应用. 专利申请号:201010291680.9.
    3. 李文鑫;   郭明雄; 汪维; 赵舟宙; 曾艳.         靶向ZNF268基因的RNA干扰表达载体构建及应用.   专利号:ZL201010230390.3.
4. 李文鑫;   郭明雄; 王涛; 汪显国; 许均华; 邱红玲; 武祥鹏. 一种ZNF300基因重组载体及应用. 专利申请号:200910273231.9
5. 李文鑫;   郭明雄; 王涛; 许均华; 汪显国; 邱红玲; 祝旋. 人ZNF300抗体在制备治疗和预防白血病药物中的应用. 专利申请号:200910063162.9.
  6. 李文鑫;   郭明雄; 赵舟宙; 邵焕杰; 孙翀.     一种ZNF268基因剪接异构体在抗白血病中的应用. 专利号:           ZL200710053681.8.
7. 陈蔚梅; 冯胜彦;   郭明雄; 艾建宇; 吴斌; 熊晓然; 吴显辉. 一种抗病毒药物利巴韦林的制备方法. 专利申请号:02115486.4.
8. 冯胜彦; 陈蔚梅; 吴斌; 熊晓然; 吴显辉;   郭明雄; 艾建宇. 一种可见光交联复合树脂固定黄嘌呤氧化酶活性细胞的方法. 专利申请号:02115489.9.
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