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qy8com千赢手机版:教师简介

刘青珍
时间:2016-12-26 12:21:06 阅读量:
职称职务:教授、博士
专 业: 病毒学
研究方向: 1.细胞凋亡相关因子的功能;
      2.病毒蛋白与宿主因子的相互作用
实 验 室: 生科院4013号房间
联系电话: +86-27-68756287 (办公室)

Email:qzhliu@whu.edu.cn

 

教学工作:
1. 分子生物学(英语教学,主讲),本科生课程,2005年至今
2. 基因工程(独立主讲),本科生课程,2006春季
3. 病毒与生命(联合主讲),本科生通识课程,2005年至今
4. 分子病毒学(主讲),研究生课程,2009年至今
5. 高级微生物学(联合主讲),研究生课程,2009年至今


教学研究课题:
主持“教育部国内外分子生物学优秀教材的比较研究”项目,2012-2013
主持“qy186 vip千嬴国际官网分子生物学全英文教学课程”项目,2011-2013
参加“教育部分子生物学双语示范课程”项目,2007获批
参加“教育部分子生物学国家精品课程”项目,2006获批
参加“湖北省教育厅分子生物学湖北省高等学校省级精品课程”项目,2006获批


学术研究课题:
2014-2017:白纹伊蚊细胞凋亡通路及其对蚊媒病毒感染的影响?国家自然科学基金面上项目 课题负责人
2011-2013:草地贪夜蛾卵巢细胞中新caspase的鉴定及功能研究 国家自然科学基金面上项目课题负责人
2009-2013:丙型肝炎病毒感染及防治的基础研究?973计划项目 参加
2010-2012:Sf9细胞中新的caspase的鉴定 高校自主科研项目 qy186 vip千嬴国际官网 课题负责人
2006-2008: 病毒抑制宿主细胞早期凋亡机制的研究 湖北省自然科学基金面上项目 课题负责人


代表性学术论文(* :通讯作者):
1.Deng Z, Yan H, Hu J, Zhang S, Peng P, Liu Q* and Guo D*: Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. 2012, PLoS One 7: e37700.


2. Onsam Sin, Prudence Mabiala, Ye Liu, Ying Sun, Tao Hu, Qingzhen Liu* and Deyin Guo. Gene silencing efficiencies and INF-β induction effects of splicing miRNA 155-based artificial miRNA with different pre-miRNA stem-loop structures. Biochemical Genetics. 2012, 50 (1-2):112-21.

3. Qingzhen Liu and Rollie Clem*. Defining the core apoptosis pathway in the mosquito disease vector Aedes aegypti: the roles of iap1, ark, dronc, and effector caspases. Apoptosis. 2011, 16(2):105-13.

4. Yang W, Qu S, Liu Q*, Zheng C*. Avian influenza virus A/chicken/Hubei/489/ 2004 (H5N1) induces caspase-dependent apoptosis in a cell-specific manner. Mol Cell Biochem. 2009, 332(1-2):233-41.

5. Qingzhen Liu* and Nor Chejanovsky*. Activation pathways and signal-mediated  up-regulation of the
insect Spodoptera frugiperda caspase-1. Apoptosis 2006, 11(4):487-96.

6. Qingzhen Liu, Yipeng Qi and Nor Chejanovsky*. Spodoptera littoralis caspase-1, a Lepidopteron effector caspase inducible by apoptotic signaling. Apoptosis 2005, 10:787-795.

7. Qingzhen Liu, Yipeng Qi, Nor, Chejanovsky. Identification and Classification of the
Spodoptera littoralis Nucleopolyhedrovirus Inhibitor of Apoptosis Gene. Virus Genes 2003,
26(2): 143-149.

8. Bryant B, Ungerer MC, Liu Q, Waterhouse RM, Clem RJ*. A caspase-like decoy molecule enhances the activity of a paralogous caspase in the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2010, 40(7):516-23.

9. Li J, Ishaq M, Prudence M, Xi X, Hu T, Liu Q, Guo D. Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2. Virus Res. 2009, 144(1-2):123-9.

10. Wu X, Zhou Y, Zhang K, Liu Q, Guo D. Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Lett. 2008, 582(15):2155-60.

11. Ishaq M, Hu J, Wu X, Fu Q, Yang Y, Liu Q, Guo D. Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Mol Biotechnol. 2008, 39(3):231-8.

12. Li J, Cai H, Liu Q, Guo D. Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus Genes. 2008, 37(1): 88-95.

13. Chen P, Jiang M, Hu T, Liu Q, Chen XS, Guo D. Biochemical characterization of exoribonuclease encoded by SARS coronavirus. J Biochem Mol Biol. 2007, 40(5): 649-55.

14. Kuang E, Wan Q, Li X, Xu H, Liu Q, Qi Y. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). J Cell Physiol. 2005: 204(2): 549-59.

15. Gan Miao, Liu Qing-Zhen, Qi Yi-Peng, Qi Bing. Polymerization of HAP hydrophobic regions and its relation with apoptosis. Chinese Journal of Biochemistry and Molecular Biology 2004, 20 (2): 117-124. (Co-first author).


16. Gan M, Qi Y, Wan Q, Kuang E, Liu Q, Liu X. Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death. Mol Biol Rep. 2004, 31(3): 159-64.
             

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