qy8com千赢手机版

ENGLISH| qy186 vip千嬴国际官网| 书记院长信箱|
当前位置: 首页 >> 教师简介 >> 正文

qy8com千赢手机版:教师简介

闫卫
时间:2020-09-18 09:58:56 阅读量:

    


 职称职务:教授

 学科专业:细胞生物学

 研究方向:外泌体与肿瘤免疫

 实验室位置:生科院大楼6128-6130
 联系电话:15871776865
 Email: weiyan@whu.edu.cn

学习经历

2005-2009  中国海洋大学大学国家海洋生命科学与技术人才培养基地,学士
       B.S. Biology, Ocean University of China, Qingdao, China

2009-2014  中科院上海生命科学研究院生物化学与细胞生物学研究所,博士
       
Ph.D. Institute of Biochemistry and Cell Biology, Shanghai Institutes
       for Biological Sciences, Chinese Academy of Sciences, Mentor:En-duo Wang


主要工作经历与任职情况:
2014-2020  美国希望之城贝克曼研究所(2014-2016)及加州大学圣地亚戈分校(2016-2020),博士后
       Post-doctoral research fellow, Beckman Institute of City of Hope and UCSD, Mentor:
       Shizhen (Emily) Wang

2020/9    qy8com千赢手机版,教授
       Professor, College of Life Sciences, Wuhan University, Wuhan, China


主要社会兼职:
2020-  Lead guest editor for research topic of Frontiers in Molecular Biosciences

2018-  Reviewer for Theranostics, Cancer Letters, Journal of Experimental & Clinical Cancer Research


主要研究领域及兴趣:
  在生物体内,细胞外囊泡Extracellular Vesicles, EV)参与细胞与细胞之间的相互通讯。其中,外泌体是直径介于30-150 nm 的一种EV,内包含蛋白质, mRNA及非编码RNA等活性成分。外泌体在肿瘤及免疫代谢疾病中参与重要的调节作用,并有望成为早期肿瘤诊断的标记物。肿瘤细胞分泌的外泌体可进入血液循环系统,从而对肿瘤微环境及远程器官具有一定的调节作用, 然而其对于肿瘤的发生及转移有无影响以及其中的调控机制尚未清楚。我们课题组主要从事肿瘤以及免疫细胞来源的外泌体对肿瘤在代谢及表观遗传层面的调控,将从细胞层面,小鼠模型及病人样本层面对肿瘤分泌的外泌体进行系统性的研究,结合单细胞测序以及质谱学探索外泌体活性成分对肿瘤微环境及各组织器官的调控机制,从而筛选出对肿瘤发生及转移重要的标记物。并进一步根据这些标记物设计出小分子抑制剂,从而服务于肿瘤的早期诊断并为治疗提供相应的科研基础。


发表的论文(*通讯作者):

Yan W, Cao M, Ruan XH, Lee S, Lemanek A, Ghassemian M, Chin AR, Duggan E, Pizzo DP, Wang D, Maio A, Nolan PJ, Schenk S*, Wang SE*. Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote muscle proteolysis. (in submission).


Yan W
, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE*. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 May;20(5):597-609. PubMed PMID: 29662176; PubMed Central PMCID: PMC5920728.


Jiang S#, Yan W#, Wang SE*, Baltimore D*. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metabolism. 2018 Feb 6;27(2):393-403.e4. PubMed PMID: 29337138.


Yan W
*, Jiang S*. Immune Cell-Derived Exosomes in the Cancer-Immunity Cycle. Trends in Cancer. 2020 March 17; DOI:https://doi.org/10.1016/j.trecan.2020.02.013.


Yan W
, Ye Q, Tan M, Chen X, Eriani G, Wang ED*. Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module. J Biol Chem. 2015 May 8;290(19):12256-67. PubMed PMID: 25817995; PubMed Central PMCID: PMC4424357.


Yan W
#, Tan M#, Eriani G, Wang ED*. Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase. Nucleic Acids Res. 2013 May;41(9):4988-98. PubMed PMID: 23525458; PubMed Central PMCID: PMC3643597.


Tan M#, Yan W#, Liu RJ, Wang M, Chen X, Zhou XL, Wang ED*. A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activity. Biochem J. 2012 Apr 15;443(2):477-84. PubMed PMID: 22292813.


Jiang S*, Yan W*. Succinate in the cancer-immune cycle. Cancer Lett. 2017 Apr 1;390:45-47. PubMed PMID: 28109906.


Jiang S*, Yan W*. T-cell immunometabolism against cancer. Cancer Lett. 2016 Nov 28;382(2):255-258. PubMed PMID: 27664755.


qy8com千赢手机版-qy186 vip千嬴国际官网