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qy8com千赢手机版:教师简介

甘菲
时间:2020-09-21 16:03:44 阅读量:

    


 职称职务:教授

 学科专业:微生物学

 研究方向:微生物合成生物学

 实验室位置:qy8com千赢手机版3011室
 联系电话:
 Email: feigan@whu.edu.cn

学习经历

2001-2005  qy186 vip千嬴国际官网(WHU);学士;生物学基地班

2005-2008  qy186 vip千嬴国际官网(WHU);硕士;微生物学

2008-2014  美国宾夕法尼亚州立大学(PSU);博士;生化,分子和微生物学


主要工作经历与任职情况:
2015-2018  美国斯克里普斯研究所(Scripps Research Institute); 博士后

2018-2019  美国加州大学伯克利分校(UC-Berkeley);博士后

2020-    qy186 vip千嬴国际官网(WHU);教授


主要社会兼职:
Frontiers in Microbiology编委


主要研究领域及兴趣:
  微生物合成生物学:(1)微生物能量代谢和生物合成。能量代谢是生命体各项生命活动的核心问题。自然界中,主要光能来源是太阳光。以光合自养型蓝细菌为对象,我们发现并揭示了蓝细菌能采用一套独特功能的光合系统、通过一种全新的机制利用远红外光光能进行产氧光合作用(Gan et al., Science, 2014),这对于理解蓝细菌生态功能和光合作用的进化,提高光合作用能量利用具有重要意义。我们将研究远红外光新型产氧光合作用的机理和进化,改造微生物体系提高生物质、生物能源和生物活性分子等产量。(2)遗传密码子扩展技术。遗传密码子扩展技术通过在生命体内引入和已有体系完全正交的氨酰tRNA合成酶/tRNA等元件,在蛋白质翻译过程中将组成蛋白质的20种天然氨基酸以外的非天然氨基酸(noncanonical amino acids,ncAAs)合成到蛋白质的特定位点。此技术被广泛用于开发具有新功能的蛋白质、生物探针、和蛋白质功能研究等领域,近年来在生物控制和生物治疗领域内展现出极大的发展前景。我们建立了以功能性替换蛋白质活性位点组氨酸来构建严格依赖于非天然氨基酸的生物体的新方法(Gan F. et al., JACS, 2018),将继续发展遗传密码子扩展技术进行蛋白质功能改造及非天然生命体构建。


发表的论文(*通讯作者):

Publication2014-

1. Pang B, Chen Y, Gan F, Yan C, Jin L, Gin JW, Petzold CJ, Keasling JD*. (2020) Investigation of indigoidine synthetase reveals conserved active site base residue of nonribosomal peptide synthetase oxidase. J Am Chem Soc. 142(25):10931–10935

2. Crnovcic I,
Gan F, Yang D, Dong LB, Schultz PG, Shen B*. (2018) Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorganic Med Chem Lett 28(16):2670-2674.

3. Gan F, Liu R, Wang F, Schultz PG*. (2018) Functional replacement of histidine in proteins to generate noncanonical amino acid dependent organisms. J Am Chem Soc. 140(11):3829-3832.

4. Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS,
Gan F, Bryant DA, Lagarias JC*. (2018) Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. J Biol Chem. 293(22):8473-8483.

5. Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C,
Gan F, Wang C, Franzblau SG, Jacobs WR, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Futterer K, Wang F*. (2017) Determinants of the inhibition of DprE1 and CYP2C9 by antibubercular thiophenes. Angew Chem Int Ed. 56(42):13011-13015.

6. Ho M-Y, Gan F, Shen G, Zhao C, Bryant DA*. (2017) Far-red light photoacclimation (FaRLiP) in the Synechococcus sp. PCC 7335. I. Regulation of FaRLiP gene expression. Photosynth Res. 131(2):173-186.

7. Ho M-Y,
Gan F, Shen G, Bryant DA*. (2017) Far-red light photoacclimation (FaRLiP) in the Synechococcus sp. PCC 7335. II. Characterization of phycobiliproteins produced during acclimation to far-red light. Photosynth Res. 131(2):187-202.

8. Fushimi K, Rockwell NC, Enomoto G, Win N-N, Martin SS,
Gan F, Bryant DA, Ikeuchi M, Lagarias JC, Narikawa R*. (2016) Cyanobacteriochrome photoreceptors lacking the canonical Cys residue. Biochemistry 55(50):6981–6995.

9. Shen G#,
Gan F#, Bryant DA*. (2016) The siderophilic cyanobacterium Leptolyngbya sp. strain JSC-1 acclimates to iron starvation by expressing multiple isiA-family genes. Photosynth Res. 128(3):325-340. (# equal contribution)

10. Zhao C,
Gan F, Shen G, Bryant DA*. (2015) RfpA, RfpB, and RfpC are the master control elements of Far-Red Light Photoacclimation (FaRLiP). Front Microbiol. 6:1303. doi: 10.3389/fmicb.2015.01303

11.
Gan F and Bryant DA*. (2015) Adaptative and acclimative responses of cyanobacteria to far-red light. Environ Microbiol. 17(10): 3450-3456.

12. Rockwell NC, Martin SS,
Gan F, Bryant DA, Lagarias JC*. (2015) NpR3784 is the prototype for a distinctive group of red/green cyanobacteriochromes using alternative Phe residues for photoproduct tuning. Photochem Photobiol Sci. 14(2): 258-269.

13.
Gan F, Shen G, Bryant DA*. (2014) Occurrence of far-red light photoacclimation (FaRLiP) in diverse cyanobacteria. Life 5(1): 4-24.

14.
Gan F, Zhang S, Rockwell NC, Martin SS, Lagarias LC, Bryant DA*. (2014) Extensive remodeling of a cyanobacterial photosynthetic apparatus in far-red light. Science 345(6202):1312-1317.


Book Chapter
1. Engineering Natural Product Biosynthetic Pathways to Produce Commodity and Specialty Chemicals. In ‘Comprehensive Natural Products III: Chemistry and Biology’ (3rd Edition), Volume 6, (2020). Elsevier, ISBN: 9780081026908


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